Alexander Tarakhovsky MD PhD

Alexander Tarakhovsky, M.D., Ph.D.

Dr. Tarakhovsky is a Professor and Head of the Laboratory for the Immune Cell Epigenetics and Signaling at The Rockefeller University. The most significant achievements of the lab include identification of the role of histone lysine methyltransferase Ezh2 in antibody repertoire formation and T cell signalling, discovery of a novel nuclear PKCd signalling pathway that causes autoimmunity, identifying the novel signalling pathway that utilises protein lysine methylation for signal-dependent lymphocyte activation and the discovery of functional histone-like sequences (histone mimics) in non-histone mammalian and viral proteins. In the course of the last few years, Dr. Tarakhovsky has collaborated with pharmaceutical companies to develop novel approaches for pharmacological control of epigenetic mechanisms of inflammation.