For any enquiries about speaking opportunities or if you have an interest in hosting one of our workshops please email Amanda Rafferty Amandarafferty@precisionmedicineforum.com
Denotes a link to the speaker's bio page.
A panel of expert speakers from across the Benelux region will share their views on what has been achieved to date in the implementation of precision medicine; where they believe it is heading in the near future; and where the focus needs to be in order to achieve key aims and objectives. Topics to be discussed include:
- Examining key advancements and enablers in the development and implementation of precision medicine
- Identifying the current legal, regulatory, societal and ethical obstacles restricting its further development
- Assessing how regulatory and healthcare frameworks in different countries need to adapt to overcome these obstacles and enable innovation and delivery:
- what can be done to improve reimbursement pathways for precision medicine to encourage better collaboration between regulators and health technology and diagnostic test providers?
Prof Dr Marc Van Den Bulcke, Head of the Cancer Centre, Sciensano
Senior Representative, EBE-EFPIA Personalised Medicine Working Group
This list is not definitive at this stage. Additional topics will be added in due course. If you would be interested in facilitating a workshop, or have ideas for topics, please contact us.
- Understanding actual vs perceived barriers to the sharing of genomic and health data:
- working with relevant stakeholders to influence and overcome these barriers
- Examining the extent to which the introduction of GDPR has impacted on the accessing and sharing of healthcare data, and how this can be managed
- Managing patient privacy and confidentiality concerns regarding healthcare data sharing
- Effectively linking patient e-health records and national data registers to establish a research database and facilitate shared decision-making
- Exploring the use and potential of blockchain-based data sharing and access
- Exploring new methods for integrating genetic data that is from different sources, in different formats, processed in different ways:
- finding the meaningful overlap and reducing “noise”
- techniques for normalising the data
- Successfully integrating lifestyle and behavioural data with biological information
- Developing robust, transparent and standardised bioinformatic pipelines to provide timely and useful clinical information
- Using new data analysis tools to gain better insights from the information available
- Techniques for reporting the findings in a coherent way: encouraging closer interactions between bioinformaticians and clinicians for better clinical reporting
- Examining how data collected from different omics can correlate with, and be analysed alongside, each other
- Developing novel methods for multi-omics data integration to extract biologically relevant information:
- how can different omics relate to the same group of patients
- Techniques for effectively integrating all omics layers into clinical trial design
- Stratification/reclassification of patients with clinically defined rheumatological diseases
- Integration of multi-cellular OMICS data generated from immune cell profiling
- Systems Immunology: from proof-of-concept to translational research
- Identifying the key challenges to biomarker validation and how to overcome these:
- determining pathways that will lead to better validation
- Changing the role and requirements of biomarkers in the design and implementation of clinical trials
- Examining the use of patient involvement in biomarker development
- Analysing the economics of biomarker development – who should pay and how can the value proposition be increased?
- Techniques to enhance and accelerate biomarker discovery and validation processes to improve their effective transition into clinical use
Chromosomal translocations are long known as drivers of leukemia, but are more recently also found as key oncogenic events in solid tumours. Consequently, such tumours are now also routinely analyzed in the clinic for the presence of these translocations. For example, translocation identification in non-small cell lung carcinomas (NSCLC) is essential to select the optimal treatment and is obligatory for the thousands of stage IV (metastatic) lung cancers in the Netherlands. Similarly, many malignant lymphomas and sarcomas are routinely analyzed for the presence of cancer-driving translocations, for diagnosis, prognosis and/or therapy choice.
In current routine clinical practice, solid tumour biopsies are stored as formalin-fixed paraffin-embedded (FFPE) material. Translocation detection in FFPE specimens is inherently difficult as the DNA is crosslinked and fragmented. Most often, microscopy-based fluorescent in situ hybridization (FISH) is applied to search for translocations. FISH has the limitation however that each translocation analysis requires a separate experiment and that results are not always conclusive.
RNA-based methods offer an alternative for translocation detection but are hampered by poor RNA quality, limited to the detection of gene fusions and only score known rearrangements. A more unbiased, robust and informative, all-in-one assay that for each tumour type simultaneously analyzes all candidate genes for any type of rearrangement, is therefore desired in the clinic.
Here we present 4C-FFPE as a novel robust NGS-based technology for the detection of clinically relevant fusion genes and non-genic translocations in FFPE tumour samples.
- Examining the emerging research into associations between the human microbiome and disease
- Understanding how individual host-microbiome associations can be integrated with other “omics” data to develop precision medicine approaches
New digital and machine-based technologies have the capability to revolutionise healthcare and drive precision medicine forward through more efficient patient-monitoring, real-time diagnoses, faster drug development, and more. This session will look at the application of new health-tech and digital developments; the benefits they are realising and the challenges to their further adoption.
- Exploring the latest innovations in mobile, smart, cloud and self-diagnostic technologies for obtaining patient data and insights
- Assessing the implications for healthcare systems of patient self-management technologies and increased patient empowerment
- Examining what tools are needed to effectively integrate e-health into clinical practice:
- creating an effective decision support framework
- identifying the key challenges to adoption and how to overcome them
- educating patients and clinics as to the potential benefits
Since chemical modifications of DNA or histones are reversible processes, there is potentially a huge benefit in modulating such modifications for the treatment of human cancers using pharmacological drugs. To achieve such anti-cancer therapy, it is essential to decipher the molecular mechanisms underlying epigenetic and epigenomic perturbations in tumours. We will present our recent efforts, to better understand and map epigenetic alterations in cancers, including DNA methylation and hydroxymethylation.
We will also discuss about our very recent work on an emerging realm of biological regulation, termed RNA epigenetics. We will present our ongoing attempts to decipher the roles of RNA modifications in cancer.
- Exploring how the journey from research to implementation could be accelerated
- Integrating technology with existing healthcare databases to give better patient knowledge and insight
- Getting big data into clinical decision support frameworks: how can the flow of health data be facilitated?
- Exploring how broad genomic profiling can be turned into valuable information that can be used quickly and easily for patients’ benefit in clinics
- Examining the impact on the healthcare professional (HCP) and their role:
- how do HCPs need to adapt to deliver the healthcare of the future?
- effectively managing increasing patient empowerment
- Communicating and convincing HCPs of the validity and potential of new personalised treatments and therapies
- Assessing the infrastructure, data and technology changes required to current healthcare systems in order to deliver a precision medicine approach
- Developing and implementing precision medicine training programmes for healthcare professionals
© Precision Medicine Forum
For programme and speaking enquiries contact email@example.com