Programme 2022
8-9 November 2022, Berlin
Scroll down for our example agenda.
For any enquiries about speaking opportunities or if you have an interest in hosting one of our workshops please email Steve Coldicott
DAY 1 - November 2022
Registration and Refreshments
Welcome and Opening Remarks
Precision Oncology: National Initiatives & Next Steps

A panel of expert speakers will outline current policy and regulations governing precision oncology, and the initiatives being implemented to further advance its clinical reality in their specific countries, including a discussion on the following aspects:

  • Identifying the current legal, regulatory and practical obstacles still restricting the advancement of precision medicine and exploring solutions to key implementation challenges
  • What progress is being made in developing national and cross-border infrastructures for data storage, registries and data sharing programmes?
  • Exploring what changes are needed to current disease and drug classification and reimbursement approaches
  • Assessing the readiness of HTA bodies to really value the benefits of innovative precision oncology (histology-independent / tumour agnostic) drugs
  • Determining what needs to be done to improve patient access to precision oncology
Networking Lunch
Advances in Diagnostics & Biomarker Development to Improve Understanding of Cancer Biology & Disease Progression, Increase Early Detection and Enable Better Stratification of Patients

The discovery and development of innovative biologically & clinically relevant biomarkers, including multi-omics biomarkers, and then integrating these, supported and justified by reliable evidence, to become part of routine clinical care is crucial to the advancement of precision oncology.  This session looks at recent advances in the development and integration of new biomarkers and diagnostic tools to improve the understanding of cancer biology, including:

  • Effectively using multi-omics analyses in precision oncology to better understand tumour development and devise appropriate treatment pathways
  • Understanding the role of epigenetics and other signatures in precision oncology
  • Implementing novel molecular characterisation strategies beyond tumour DNA sequencing, eg transcriptomics, immunophenotyping, and single-cell analyses
  • Liquid Biopsy: Circulating tumour DNA & blood-borne biomarkers as precision diagnostic tools
  • Successfully leveraging the information derived from digital biomarkers and telemedicine and assessing their use as diagnostic tools in practice
  • Usefully interpreting increasingly complex laboratory and test reports and developing an effective clinical trial biomarker strategy
Refreshments and Networking
Delegates move to their chosen roundtable session
Roundtable Discussion Sessions
This session is intended to give participants the opportunity to discuss a specific topic in a more informal, participative format. Delegates may choose one roundtable to attend, and each table will be led by a facilitator who will outline some structured points for discussion and encourage optimum debate and exchange of ideas.
A. Translating Biological Research & Big Data into Actionable Insights for Use in Clinics
B. Maximising the Potential of Molecular Tumour Boards in Understanding Tumour Evolution
C. Optimising AI and E-Health Solutions to Advance Precision Oncology
D. Evaluating the Potential of CAR-T Cells for Advancing Precision Oncology
E. Developing the Use of Pharmacogenomics for Personalised Drug Therapy
F. The Role of Epigenetics in Precision Oncology
G. Exploring the Development and Use of Histology-Agnostic Biomarkers
H. Advancing Imaging: Exploring the Use of Radiomics (with AI) to Predict Patient Outcomes and Treatment Response
Roundtable Feedback
Each roundtable facilitator will briefly share the key learning points from their table discussion with the audience.
Close of Day One followed by a Complimentary Networking Drinks Reception
DAY 2 - November 2022
Welcome Refreshments and Networking
Opening Remarks from the Chair
Effective Tumour Molecular Profiling to Enable Individual Personalised Treatment Decisions
The clinical and molecular heterogeneity of tumours and their evolution after diagnosis and treatment presents major challenges to effective cancer therapy. Understanding what 'steps' a cell must take to become cancerous, as well as the influence of external factors such as inherited genetic factors, metabolic profiles, and lifestyle factors and being able to unravel the mechanisms of drug resistance are all fundamental to the development of precision oncology strategies. Molecular Tumour Boards play an increasingly critical role in cancer diagnosis and treatment and advances in these, including the development of virtual molecular tumour boards (vMTB), will further enable the development of new solutions in oncology clinical practice.
Morning Refreshments & Networking
Innovative Clinical Trial Design for Precision Oncology

New approaches to clinical trials have the potential to accelerate research and drug development so that the right therapies can rapidly be delivered to the right patients. However there are a number of issues affecting progress such as regulatory and reimbursement constraints due to the cost and complexity of clinical trial design. This session will explore key issues including:

  • The latest thinking in clinical trial design: platform, umbrella, basket, histology-agnostic and incorporating AI into trial design
  • Determining what changes need to be made to current trial design to better enable a precision approach
  • Exploring the the benefits of Randomised Clinical Trials (RCTs) vs Real-World Evidence (RWE) for guiding treatment and drug development decisions
  • Integrating real-world data with other information sources to select the “right” patients
  • Detailing what payers need to see in order to fund and support access to targeted therapy.
  • Patient empowerment in the clinical trial and drug development process
    Making Best Use of the Data Available: Strategies for Sharing, Analysing & Interpreting Patient & Clinical Data

    A vital step in the advancement of precision oncology is the effective analysis and interpretation of real-life data, extracting meaningful information from large volumes of complex data in order to give the clinician a carefully refined list of targets and actionable insights, thus aiding their decision-making. This session will discuss best practice in the collection, analysis and management of data and exploiting new data tools in order to drive real change in clinical practice.

    • Identifying the most useful types of data to collect, and the key obstacles to effective access and sharing: overcoming the challenges of harmonising biomarker data
    • Exploring the use of real-world data (RWD) and learning from patients who do not respond as expected
    • Discussing the potential of AI for analysing patient and clinical data
    • Overcoming the complexity of reporting actionable targets
    Networking Lunch
    Immuno-Oncology: Exploring Advances in Developing Cancer Immunotherapies

    There are huge expectations for cancer immunotherapies and their potential to manipulate the patient’s own immune system in order to fight tumour cells and treat the disease. Whilst much progress has been made in this area, there have also been set-backs and the price, hope and hype associated with cancer immunotherapy places a lot of pressure on clinicians. This session will explore new approaches for  optimising response and minimising resistance to cancer immunotherapies.

    • Assessing the type of cancer to which immunotherapy will be most beneficial and implementing it in a personalised approach:
      • developing different therapies for different patients and cancers
      • determining likely time-scales for regulatory guidance for actively personalised immunotherapies
    • Exploring the evolution and development of CAR-T cells for effective immunotherapy and precision oncology:
      • identifying novel targets for CAR-T cells
      • Increasing their effectiveness for solid tumours
      • understanding mechanisms of resistance to CAR-T cell therapy 
      • exploring next-generation cell therapies and the potential of CAR NK cells
    • Examining the potential of neoantigens for cancer immunotherapy
    Exploring the Digital Innovations Transforming Precision Oncology Research & Healthcare

    This session will explore the advances in, and application of, innovative technologies to drive a truly personalised approach, including:

    • Radiomics & the Use of Imaging Technology for a Precision Approach to Diagnostics & Treatment 
    • Harnessing the Potential of Digital Pathology for Precision Medicine
    • Challenges, Opportunities and New Applications for Artificial Intelligence (AI) in Precision Oncology
    Final Audience Discussion: Making It A Reality - Implementing Precision Oncology into Clinical Practice
    This final audience discussion brings together many of the points discussed throughout the 2 days into some parting thoughts: how can we overcome the challenges of bringing molecular and genomic research & testing into routine clinical care and facilitate the journey from bench to bedside?
    Close of Conference - Refreshments will be Served
    With Special Thanks to Our Sponsors, Exhibitors and Partners
    © Precision Medicine Forum