Prof.dr. Peter-Bram ’t Hoen started in February 2018 as full professor in bioinformatics at Radboud University Medical Center Nijmegen and head of the Centre for Molecular and Biomolecular Informatics. Before that, he was postdoc, assistant and associate professor in the Human Genetics department at Leiden University Medical Center. His group studied the aetiology of rare muscular dystrophies using state-of-the-art molecular technologies. He was among the first researchers in the Netherlands to implement microarray and (novel) RNA-sequencing technologies, and organized many (inter)national courses on these topics. With these new technologies, he identified major players and mechanisms in the transcriptional and post-transcriptional regulation of gene expression in health and disease.
His main drive is to optimally analyze and interpret large (multi)-omics data sets. In their interpretation, he typically goes beyond standard (pathway) analysis methods and develops and employs automated knowledge discovery approaches and new statistical routines. This resulted in the prediction and validation of novel biomarkers, novel protein:protein interactions, and new candidate drugs. His current research interest is mainly in the development of new personalized treatment strategies based on a combination of molecular and clinical data. ’t Hoen leads the data analysis, integration and stewardship pillar in X-omics, one of the large national research infrastructures. He is member of the executive committee of the RD-Connect community fostering data sharing and integration for rare diseases.
‘t Hoen is active in the European Joint Programme on Rare Diseases and board member of the research working group European Reference Network on neuromuscular diseases (EURO-NMD). He is also co-leading the Personal Health Train consortium, developing a data infrastructure to advance healthcare and biomedical science through interoperable and federated data management.
He has published >150 papers in peer-reviewed scientific journals and his h-index is 47 (January 2019; Google Scholar).
Employment and education
From Feb 2018 Professor of Bioinformatics, director of the Center for Molecular and Biomolecular Informatics, RadboudUMC, Nijmegen
2011 – 2017 Associate professor department of Human Genetics (LUMC), heading the bioinformatics research group
2010 – 2011 Assistant professor department of Human Genetics (LUMC),
2002 – 2009 Post-doctoral researcher department of Human Genetics (LUMC)
2002 Ph.D. Biopharmaceutical sciences (Leiden / Amsterdam Center for Drug Research)
1997 Master of Science Degrees in Biochemistry and Pharmacochemistry (Vrije Universiteit, Amsterdam), both with honors