Ramin Shiekhattar is the Director of Cancer Epigenetics Program, Chief of Division of Cancer Genomics & Epigenetics and Professor of Human Genetics at the University of Miami Miller School of Medicine. His laboratory has made a number of seminal discoveries identifying and characterizing important mediators of epigenetic regulation and noncoding RNA processing that contribute to cancer development. Currently, the laboratory is exploring a class of long noncoding RNAs that arise from enhancer elements and behave similar to transcriptional enhancers. Importantly, the laboratory has pinpointed the RNA polymerase II-associated multiprotein complex, Integrator, as a critical component of the biogenesis machinery for these enhancer RNAs (eRNAs). The laboratory is interested in deciphering the function of Integrator and eRNAs in the context of relevant models of development and disease, using state of the arts genomics and proteomics approaches.